During the Who's Bill This Time? round, P.J. O'Rourke announced that he was endorsing Hillary Clinton for President.
During the Not My Job round, after Rachel Bloom was given an opportunity to change her answer for the third question, Helen Hong "quietly" provided a strong hint at the correct answer. Rachel Bloom changed her answer to the correct one.
After Tom Bodett answered all eight Lightning Fill-in-the-Blank questions correctly, Bill Kurtis mentioned that "no one does it". There have been, at minimum, 30 instances where a panelist has answered all 8 questions correctly. Before this show, Tom Bodett has done so, at minimum, 3 times.