The show was recorded remotely.

Peter and Mara Sagal welcomed their new baby, Elliott Sagal, on 2020-11-29. Maz Jobrani is filling in as guest host for Peter.

Eugene Cordero answered his third Lightning Fill-in-the-Blank question with "Word of the Day" where "Word of the Year" was the correct answer. Maz accepted it as a correct answer and gave Eugene points. In the edited version of the show, Eugene was asked 4 questions and had 3 of them correct. Bill Kurtis said that Eugene answered 4 correct.

Jessi Klein initially answered her fifth Lightning Fill-in-the-Blank question with "lion" but quickly changed it to "kangaroo;" which, was the correct answer and was given points.

This is the first time since January 2000 in which more than one panelist answered all 8 Lightning Fill-in-the-Blank questions correct. As of this show, scoring data is not available for shows that aired prior to January 2000.

The show was recorded remotely.

The name of the person whose audio clip was used to reveal the correct Bluff the Listener story is Eva Wolchover; which, is the name of a former producer for Wait Wait... Don't Tell Me!

All three choices for the third Not My Job question involved Dame Judy Dench. Another instance where all three of the correct choices were "B".

Maz Jobrani accepted Maeve Higgins' answer of "some kind of space company" as it included the word "space" for her fifth Lightning Fill-in-the-Blank question. Maz also accepted Maeve's answer of the opposite of anti-depressant for her sixth Lightning question; where, the correct answer was erectile dysfunction pills.

Adam Burke answered his sixth Lightning question with "Aurora Borealis" and Maz initially didn't accept the answer by saying the correct answer was the "Northern Lights". Adam said that the Northern Lights are also known as the Aurora Borealis and Maz accepted the answer.

The show was recorded remotely.