The show was recorded remotely.

Peter and Mara Sagal welcomed their new baby, Elliott Sagal, on 2020-11-29. Maz Jobrani is filling in as guest host for Peter.

Eugene Cordero answered his third Lightning Fill-in-the-Blank question with "Word of the Day" where "Word of the Year" was the correct answer. Maz accepted it as a correct answer and gave Eugene points. In the edited version of the show, Eugene was asked 4 questions and had 3 of them correct. Bill Kurtis said that Eugene answered 4 correct.

Jessi Klein initially answered her fifth Lightning Fill-in-the-Blank question with "lion" but quickly changed it to "kangaroo;" which, was the correct answer and was given points.

This is the first time since January 2000 in which more than one panelist answered all 8 Lightning Fill-in-the-Blank questions correct. As of this show, scoring data is not available for shows that aired prior to January 2000.